Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?
Identifieur interne : 005394 ( Main/Exploration ); précédent : 005393; suivant : 005395Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?
Auteurs : D. Rejman [République tchèque] ; J. Snásel ; R. Liboska ; Z. Tocík ; O. Paces ; S. Králíková ; M. Rinnová ; P. Kois ; I. RosenbergSource :
- Nucleosides, nucleotides & nucleic acids [ 1525-7770 ]
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Oligonucléotides antisens, Ribonuclease H.
- synthèse chimique : Oligonucléotides antisens.
- AMP, Hybridation d'acides nucléiques, Oligonucléotides antisens, Phosphonates, Réactifs réticulants, Thymidine monophosphate.
English descriptors
- KwdEn :
- Adenosine Monophosphate (chemistry), Cross-Linking Reagents (chemistry), Nucleic Acid Hybridization, Oligonucleotides, Antisense (chemical synthesis), Oligonucleotides, Antisense (chemistry), Oligonucleotides, Antisense (metabolism), Organophosphonates (chemistry), Ribonuclease H (metabolism), Thymidine Monophosphate (chemistry).
- MESH :
- chemical , chemical synthesis : Oligonucleotides, Antisense.
- chemical , chemistry : Adenosine Monophosphate, Cross-Linking Reagents, Oligonucleotides, Antisense, Organophosphonates, Thymidine Monophosphate.
- chemical , metabolism : Oligonucleotides, Antisense, Ribonuclease H.
- Nucleic Acid Hybridization.
Abstract
Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.
DOI: 10.1081/NCN-100002437
PubMed: 11563123
Affiliations:
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Le document en format XML
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Rejman</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague 6</wicri:regionArea><wicri:noRegion>166 10 Prague 6</wicri:noRegion></affiliation></author><author><name sortKey="Snasel, J" sort="Snasel, J" uniqKey="Snasel J" first="J" last="Snásel">J. Snásel</name></author><author><name sortKey="Liboska, R" sort="Liboska, R" uniqKey="Liboska R" first="R" last="Liboska">R. Liboska</name></author><author><name sortKey="Tocik, Z" sort="Tocik, Z" uniqKey="Tocik Z" first="Z" last="Tocík">Z. Tocík</name></author><author><name sortKey="Paces, O" sort="Paces, O" uniqKey="Paces O" first="O" last="Paces">O. Paces</name></author><author><name sortKey="Kralikova, S" sort="Kralikova, S" uniqKey="Kralikova S" first="S" last="Králíková">S. Králíková</name></author><author><name sortKey="Rinnova, M" sort="Rinnova, M" uniqKey="Rinnova M" first="M" last="Rinnová">M. Rinnová</name></author><author><name sortKey="Kois, P" sort="Kois, P" uniqKey="Kois P" first="P" last="Kois">P. Kois</name></author><author><name sortKey="Rosenberg, I" sort="Rosenberg, I" uniqKey="Rosenberg I" first="I" last="Rosenberg">I. Rosenberg</name></author></analytic><series><title level="j">Nucleosides, nucleotides & nucleic acids</title><idno type="ISSN">1525-7770</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine Monophosphate (chemistry)</term><term>Cross-Linking Reagents (chemistry)</term><term>Nucleic Acid Hybridization</term><term>Oligonucleotides, Antisense (chemical synthesis)</term><term>Oligonucleotides, Antisense (chemistry)</term><term>Oligonucleotides, Antisense (metabolism)</term><term>Organophosphonates (chemistry)</term><term>Ribonuclease H (metabolism)</term><term>Thymidine Monophosphate (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>AMP ()</term><term>Hybridation d'acides nucléiques</term><term>Oligonucléotides antisens ()</term><term>Oligonucléotides antisens (métabolisme)</term><term>Oligonucléotides antisens (synthèse chimique)</term><term>Phosphonates ()</term><term>Ribonuclease H (métabolisme)</term><term>Réactifs réticulants ()</term><term>Thymidine monophosphate ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Oligonucleotides, Antisense</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Adenosine Monophosphate</term><term>Cross-Linking Reagents</term><term>Oligonucleotides, Antisense</term><term>Organophosphonates</term><term>Thymidine Monophosphate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Oligonucleotides, Antisense</term><term>Ribonuclease H</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Oligonucléotides antisens</term><term>Ribonuclease H</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Oligonucléotides antisens</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Nucleic Acid Hybridization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>AMP</term><term>Hybridation d'acides nucléiques</term><term>Oligonucléotides antisens</term><term>Phosphonates</term><term>Réactifs réticulants</term><term>Thymidine monophosphate</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.</div></front></TEI><affiliations><list><country><li>République tchèque</li></country></list><tree><noCountry><name sortKey="Kois, P" sort="Kois, P" uniqKey="Kois P" first="P" last="Kois">P. Kois</name><name sortKey="Kralikova, S" sort="Kralikova, S" uniqKey="Kralikova S" first="S" last="Králíková">S. Králíková</name><name sortKey="Liboska, R" sort="Liboska, R" uniqKey="Liboska R" first="R" last="Liboska">R. Liboska</name><name sortKey="Paces, O" sort="Paces, O" uniqKey="Paces O" first="O" last="Paces">O. Paces</name><name sortKey="Rinnova, M" sort="Rinnova, M" uniqKey="Rinnova M" first="M" last="Rinnová">M. Rinnová</name><name sortKey="Rosenberg, I" sort="Rosenberg, I" uniqKey="Rosenberg I" first="I" last="Rosenberg">I. Rosenberg</name><name sortKey="Snasel, J" sort="Snasel, J" uniqKey="Snasel J" first="J" last="Snásel">J. Snásel</name><name sortKey="Tocik, Z" sort="Tocik, Z" uniqKey="Tocik Z" first="Z" last="Tocík">Z. Tocík</name></noCountry><country name="République tchèque"><noRegion><name sortKey="Rejman, D" sort="Rejman, D" uniqKey="Rejman D" first="D" last="Rejman">D. Rejman</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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